The down-hole engineering parameters measure while drilling system is an important vehicle to monitor the down-hole parameters in the drilling process. By adopting it, the drilling engineer can grasp the engineering parameters of annulus pressure, drilling pressure, torque, temperature and so on. In real-time way, it can be used to learn and analyze the state of down-hole. The down-hole engineering parameters measure while drilling system adopts the Infineon XC886 MCU as the core chip, and uses the high reliability technology to complete the engineering parameters measuring dual system. The down-hole engineering parameters measure while drilling system has advantages of small size, low power consumption, vibration resistance and high temperature flexibility. Once the overall system is completed, to realize its engineering application, laboratory test, high temperature test, vibration test and spot test are made to check the function and the reliability of the system, and the field data in the spot test are successfully obtained.