Romanian business environment is constantly changing, recording successive fluctuations, both in terms of growth and those regarding the "performance" factor. As a result, the development of entrepreneurship has transformed over the last decade in a process generating economic growth and welfare, while the results were correlated with a number of social and technological progress. The present paper aims therefore to describe how encouraging entrepreneurship, at both national and regional level, can help ensure sustainable economic growth. It has been followed, also, the regionally dynamics of SMEs, in the idea of determining the main influences that ensures positive economic results.