Perioperative cerebrovascular accidents after general anesthesia are rare but devastating, and are often fatal. We experienced a case of acute cerebral infarction found at 2 days after general anesthesia. A 64 year old, ASA physical status II, hypertensive male patient underwent radical neck dissection due to right thyroid cancer. Anesthesia was induced with propofol and succinylcholine and maintained with vecuronium-enflurane-nitrous oxide-oxygen. No special event occurred during anesthesia, except for of three hypotensive events that required ephedrine. On the second day after the operation, he complained dysarthria and left facial weakness. Brain CT and MRI revealed an infarction of the right middle cerebral artery territory. He was transferred to the department of neurology and received conservative care. Fortunately, he was discharged at 20 days after surgery with much improved symptoms.