Systemic lupus erythematosus (SLE) is a multisystem inflammatory disorder characterized by autoantibody production. It has a strong female preponderance and occurs primarily in the reproductive years. Although involvement of the respiratory system is common in SLE, pneumothorax is one of the less frequently reported pulmonary complications and carries with it a grave prognosis. We report a successful anesthetic management of a parturient with SLE complicated by pneumothorax.