A 39-yr-old female patient, diagnosed with tuberous sclerosis 10 years ago, presented for selective arterial embolization under general anesthesia. The symptoms of the patient were lower abdominal pain and gross hematuria. Renal arteriography showed multiple bilateral renal angiomyolipomas and ruptured aneurysms in right kidney. She had also pulmonary lymphangiomyomatosis, hepatic angiomyolipomas, and multiple subependymal nodules without mass effect in brain. We report the anesthetic management of this case with tuberous sclerosis for selective arterial embolization under general anesthesia.