BACKGROUND: A paracervical C2 ganglion blockade was carried out for therapeutic and diagnostic reasons of cervicogenic headache only. METHODS: This study was designed to investigate the therapeutic effect of C2 ganglion blockade in patients with cervicogenic headache(CEH), migraine without aura, and tension-type headache(TTH). From March 1995 to June 1995, we treated 24 cases of chronic headache(CEH:12, TTH:9, migraine:3) using C2 ganglion blockade with methylprednisolone and mepivacaine. The diagnoses of CEH in this study was established according to the recent diagnostic criteria(Sjaastad et al. 1990). The diagnoses of migraine and TTH were based on the IHS criteria. RESULTS: In the cases of cervicogenic headache, 11 patients out of 12(91.67%) improved after C2 ganglion blockade. In the cases of tension-type headache, 7 patients out of 9 improved(77.78%). In the cases of migraine, 1 patient out of 3(33.33%) improved. CONCLUSION: No significant differences of the therapeutic value were found in patients with three groups of headache(Fishers exact test).