Submandibular gland enlargement in assoication with general anesthesia is an unusual complication and easy to be unnoticeable. This report describes a case of bilateral enlargement of submandibular gland that developed just after failure of inserting Intubating LMA (ILMA) during stormy induction. The submandibular gland enlargement was benign, rubbery in consistency, without crepitus and not massive to inhibit ventilation. The patient's airway could be maintained with LMA. The mechanism of the occurrence remains unknown, but several factors that are most closely associated with this event are parasympathetic hyperactivity, physical obstruction by ILMA. This enlagement was gradually decreased in size within 1 hour and massaged gently and could not be palpated 3 hours later.