BACKGROUND: Surgical repair of a hip fracture and a total hip replacement (THR) are mostly performed in elderly patients. The overall perioerative mortality is 0.5 to 1.0%, for which one of the common causes is pulmonary embolism during the postoperative period. A number of studies have demonstrated reduction in both perioperative blood loss and incidence of postoperative thromboembolism after a total hip replacement with spinal or epidural anesthesia. However a regional technique is often inappropriate for the patient scheduled for a THR because of the long operating time, the positioning and the manipulation required during the procedure. Even though combined epidural-general anesthesia may offer advantages for the patient undergoing a THR, until now the effects of such a technique for a THR have not been reported. The aim of this study was to compare the effects of general anesthesia (GA) and combined epidural-general anesthesia (CEGA) on blood loss, incidence of postoperative thromboembolism and effective postoperative pain control on patients undergoing a THR. METHODS: Thirty cases of both GA and CEGA for a THR performed at the department of anesthesiology, Keimyung University Dongsan Hospital from Jan. to Dec. 1999 were selected. The surgical time, volume of intravenous fluid infusion during the operation, intraoperative and postoperative transfusion volume, preoperative and postoperative hemoglobin, postoperative blood loss, use of postoperative analgesics, and incidence of postoperative thromboembolism were measured. RESULTS: Surgical time, volume of intravenous fluid administration during the operation and the use of postoperative analgesics was significaltly less in the group CEGA (P < 0.05). Mean values of intraoperative and postoperative transfusion volume, differences between preoperative and postoperative hemoglobin and postoperative blood loss were less in the CEGA group than in GA group. However, the differences were not found to be statistically significant. No difference was found between the two groups in incidence of postoperative thromboembolism. CONCLUSIONS: CEGA decreases surgical time, volume of intravenous fluid administration during an operation and provides effective postoperative pain control in patients undergoing a THR. Therefore,it is suggested that CEGA offers some advantages over GA alone.