Brugada syndrome describes a subgroup of patients at risk of ventricular fibrillation, but with no evidence of an underlying structural heart disease associated with an ECG pattern of right bundle branch block and a ST segment elevation in the right precordial leads (V1 to V3). This syndrome is familial with an autosomal dominant mode of transmission, and may be considerably more common in Southeast Asia. It is associated with a significant risk of ventricular tachyarrhythmias and sudden death, which is not effectively prevented by anti-arrhythmic drug therapy. We experienced such a case under general anesthesia for a hemi-colectomy, in a 32-year-old male patient diagnosed as having Brugada syndrome by characteristic ECG findings without untoward cardiovascular events.