Brugada syndrome is characterized by a distinctive electrocardiographic pattern (right bundle branch block and a ST segment elevation in the right precordial leads), but without structural heart disease. It is a rare genetic disorder, with an autosomal dominant inheritance pattern. Many factors during general anesthesia (medication, bradycardia, temperature changes) can precipitate malignant dysrhythmia in this patient, so careful choice of anesthetics is required. We experienced the anesthetic management of a 50-year-old male patient with Brugada syndrome, who underwent an emergency operation, under general anesthesia for acute appendicitis. Surgery was performed uneventfully, and the patient was discharged without complication.