BACKGROUND: Continuous epidural block is an effective method for pain relief. It should be performed with sterile instrumentation to protect against infection by the indwelling catheter. METHODS: Sixty-two patients were examined by means of the presence of infection with a bacterial culture using the pieces of the catheter at the epidural space and subdermal area. We studied the relationship among infection and the indwelling period of the catheter, patient's age and sex, indwelling site of catheter, and rash and induration on the skin. In addition, we observed the relationship between subdermal infection and epidural infection. When bacteria species were identified, an antibiotic sensitivity test was performed. RESULTS: The rate of infection of the epidural space and subdermal area were 25.8% in both. There was no relationship among infection and the indwelling period of the catheter, patient's age and sex, indwelling site of catheter, or rash and induration on the skin. Gram positive coagulase negative Staphylococcus was most commonly observed. Meanwhile the Enterococcus faecalis was most commonly observed at the caudal area. Most colonies of bacterias responded to aminopenicillin and 1st and 2nd generation cephalosporins in the antibiotics sensitivity test. CONCLUSIONS: We recommend that perfect sterilization and effective management of indwelt catheters and skin are required. If necessary, it may be possible to consider the preventive use of antibiotics.