A 30-year-old female underwent emergency cesarean section with general anesthesia. In the past history, she has no specific problem. After delivery of fetus and placenta, there was continuous uterine bleeding due to uterine atony. Surgeon injected 1 mg of sulprostone (prostaglandin E2) into the uterine muscle and 1 mg of sulprostone was injected intravenously. One hour after sulprostone injection, high fever was detected. Sulprostone has been known to have side effects such as nausea, vomiting, uterine rupture, pulmonary edema and fever. Therefore, when we inject sulprostone into the uterine atonic bleeding patient, it is necessary to pay attention to fever for it's complication, in giving overdose.