Numerous complications may accompany the central venous catheterization. The followings have been reported after central venous catheterization as complications: thrombophlebitis, air embolism, pneumothorax or hydrothorax, subcutaneous emphysema, cardiac tamponade and perforation of a major structure. Late perforation of vascular structures by central venous catheter tips are unusual, but potentially lethal complication. We report a case of lethal hemomediastinum after catheterization with a central venous catheter.