We report a case of a suspected acute hepatic dysfunction after general anesthesia with sevoflurane. A 71 year old female underwent a laparoscopic appendectomy under O₂-N₂O-sevoflurane anesthesia. She had no history of anesthesia, allergy, hypertension, diabetes or hepatitis. Four hours after surgery, she developed a conscious disturbance and became comatose. There was a marked increase in the serum aspartate aminotransferase, alanine aminotransferase, activated partial thromboplastin time and prothrombin time level, but the platelet and eosinophil counts were within the normal range. Her hepatic dysfunction improved after conservative therapy. She recovered gradually and was discharged after 24 days of hospitalization. Sevoflurane is believed to be the possible cause of the acute hepatic dysfunction in this case.