期刊名称:Iranian Journal of Psychiatry and Clinical Psychology
印刷版ISSN:1735-4315
电子版ISSN:2228-7515
出版年度:2007
卷号:13
期号:2
页码:89-96
语种:English
出版社:Tehran University of Medical Sciences
其他摘要:Abstract Objectives: This study aimed to evaluate and compare neurological soft signs (NSS) in patients with first episode psychosis, in their first-degree relatives, and in healthy control subjects. Method: Thirty patients with first-episode psychosis, 30 of their first-degree relatives, and 30 healthy controls were evaluated by the Structured Clinical Interview for DSM-IV (SCID) for psychiatric assessment. Neurological Evaluation Scale (NES) was used for the evaluation of NSS, and Edinburgh Handedness Inventory (EHI) for laterality assessment. Data were analyzed by the following statistical tests: Chi-square, t-test, Fisher’s Exact Test, Kolmogorov-Smirnov Test, and non-parametric tests of Kruskal-Wallis and Mann-Whitney. Results: First-episode psychotic patients had significantly higher NES total scores than the first-degree relatives, and the control group. On “sequencing of complex motor acts”, “motor coordination”, and “sensory integration” subscales of the NES, patients had significantly higher scores than the controls (respective p-values of Conclusion: A higher prevalence of NSS occurs in patients with first-episode psychosis than in their relatives or healthy control subjects. Neurological soft signs are part of a neural dysfunction that underlies psychosis rather than the consequence of a neurodegene-rative processes caused by the disease.
关键词:سایکوز بار اول; نرمنشانههای عصبی; اسکیزوفرنیا