摘要：The importance of endodontic treatment is to achieve a complete filling and sealing of the root canal to prevent the transport of contaminants to and from root canal, with materials compatible with the surrounding tissues. Occasionally a situation may arise in which the purpose of the maintenance of working length is compromised such as overenlargement. This situation allows the extrusion of filling materials, mainly sealer cements, causing post treatment complications such as inflammatory reactions, injury to adjacent structures (orbital pain, inferior alveolar nerve injury, headache, etc.), and infections in the sinuses caused by aspergillosis. AH Plus cement seems to show favorable results. In cases of extrusion of small amounts to the periapical space, due to the addition of epoxy amines to its composition, there is a decrease in the release of toxins, and according to some authors, the possible cytotoxic effects cease once the material hardens. Keywords: Endodontics, periapical tissue, root canal filling materials, biocompatible materials, epoxy resins, toxic actions.
