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  • 标题:Roles of NMDA and dopamine in food-foraging decision-making strategies of rats in the social setting
  • 本地全文:下载
  • 作者:Fang Li ; Wen-Yu Cao ; Fu-Lian Huang
  • 期刊名称:BMC Neuroscience
  • 印刷版ISSN:1471-2202
  • 电子版ISSN:1471-2202
  • 出版年度:2016
  • 卷号:17
  • 期号:1
  • 页码:1
  • DOI:10.1186/s12868-015-0233-8
  • 语种:English
  • 出版社:BioMed Central
  • 摘要:Background In highly complex social settings, an animal’s motivational drive to pursue an object depends not only on the intrinsic properties of the object, but also on whether the decision-making animal perceives an object as being the most desirable among others. Mimetic desire refers to a subject’s preference for objects already possessed by another subject. To date, there are no appropriate animal models for studying whether mimetic desire is at play in guiding the decision-making process. Furthermore, the neuropharmacological bases of decision-making processes are not well understood. In this study, we used an animal model (rat) to investigate a novel food-foraging paradigm for decision-making, with or without a mimetic desire paradigm. Results Faced with the choice of foraging in a competitive environment, rats preferred foraging for the desirable object, indicating the rats’ ability for decision-making. Notably, treatment with the non-competitive N-methyl- d -aspartate receptor antagonist MK-801, but not with the dopamine D1 or D2 receptor antagonists, SCH23390 and haloperidol, respectively, suppressed the food foraging preference when there was a competing resident rat in the cage. None of these three antagonists affected the food-foraging preference for palatable food. Moreover, MK-801 and SCH23390, but not haloperidol, were able to abolish the desirable environment effect on standard food-foraging activities in complex social settings. Conclusions These results highlight the concept that mimetic desire exerts a powerful influence on food-foraging decision-making in rats and, further, illustrate the various roles of the glutamatergic and dopaminergic systems in mediating these processes.
  • 关键词:Food-foraging behavior ; Social decision-making ; Mimetic desire ; Rats
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