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  • 标题:SYNTHESIS AND BIOLOGICAL ACTIVITY OF NICKEL AND COPPER COORDINATION COMPOUNDS OF 5-NITROFURAN-2-CARBALDEHYDE N(4)-ALLYL-3-THIOSEMICARBAZONE
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  • 作者:Vasilii GRAUR ; Elena ZARICIUC ; Victor TSAPKOV
  • 期刊名称:Studia Universitatis Moldaviae: Stiinte Sociale
  • 印刷版ISSN:1814-3199
  • 电子版ISSN:2345-1017
  • 出版年度:2014
  • 卷号:6
  • 期号:76
  • 页码:119-123
  • 出版社:Moldova State University
  • 摘要:The paper presents the synthesis of the ligand 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone (HL) and eight coordination compounds of copper(II) and nickel(II) with this ligand. The structure of thiosemicarbazone HL was studied using 1 H and 13 С NMR spectroscopy. For the synthesized compounds their antimicrobial and antifungal activity was studied on a series of standard strains. For HL and Cu(HL) 2 (NO 3 ) 2 the antitumor activity towards human leukemia HL-60 cells was estimated. It was established that coordination compounds manifest better activity than free ligand
  • 关键词:complexes; 5-nitrofuran-2-carbaldehyde; thiosemicarbazone; biological activity
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