摘要：The emergence of antimicrobial resistant strains of pathogenic bacteria has become a great threat to the public health. One of the main risk factor fo r spreading of resistant bacteria is selective pressure by intense and inadequate antibiotic human therapy and increase the antibiotic resistance phenomenon in bacterial strains from natural sources. Certain bacteria have multidrug resistance to antibiotics by extended spectrum beta lactamases (ESBLs) synthesis, under plasmidial genes or transposable elements control. Resistance to fluoroquinolones and extended spectrum beta lactamases synthesis in E. coli strains limit the therapeutic options for patients with such infections. In this study 1625 urine samples from patients with suspicion of urinary tract infections were collected in the laboratory of MEDAS Medical Centre, from children and adult patients and processed by qualitative and quantitative urine cultures. The E. coli strains isolated from urine samples were tested for presence of ESBLs, 24% from E. coli strains were ESBL producers and justify the interest for this resistance mechanism
