期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2015
卷号：6
期号：8
页码：2083-2088
出版社：University of Mohammed Premier Oujda
摘要：The new series of Schiff base were synthesized from 7-methyl-2-phenylimidazo[1,2-a]pyridin-3-amine condensed with different substituted aldehydes (4-Hydroxybenzaldehyde, Vanillin, 3-Nitrobenzaldyde, 4- Nitrobenzaldehyde)in presence of catalytic quantities of acetic acid. So the structure offers for this synthesis well coincide with the results obtained bydifferent spectroscopic techniques (IR, 1 H NMR, 13 C NMR and Mass spectroscopy). These new compounds were evaluated for their antibacterial, againstGram positive and Gram negative bacteria, and antifungal activityagainst yeasts and moulds, using micro-dilution tests. The biological activityof the synthesized compoundswere compared with standard drugs. The best results are observed in the amine starting (new 7-methyl-2-phenylimidazo [1,2-a]pyridin-3-amine), it showed interesting antibacterial activity of all tested strains, particularly against Proteus strain is a Gram -.
