期刊名称：Journal of Materials and Environmental Science
印刷版ISSN：2028-2508
出版年度：2016
卷号：7
期号：1
页码：356-361
出版社：University of Mohammed Premier Oujda
摘要：A series of new 5 - ((4 - Alkyl piperazin - 1 - yl) methyl) quinolin - 8 - ol derivatives were synthesized starting from the properly substituted 4 - piperazine, by condensation with 5 - chloromethyl - 8 - quinolinol in the presence of triethylamine. The structures of all the compounds were identified by 1 H NMR and 13 C NMR. The 5 - Chloromethyl - 8 - Quinolinol hydrochloride (CMQ) was also characterized by IR spectra. The antibacterial activity of the newly synthesized compounds was evaluated and screened "in vitro" using the disc diffusion technique against Gram - positive and Gram - negative bacterial strains .The antibacterial screening results reveal ed that among the fourth compounds screened, three of them, showed a very good antibacterial activity compared to t he standard antibiot ic
