期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：1
页码：19069
DOI：10.15680/IJIRSET.2015.0401085
出版社：S&S Publications
摘要：The selection of an appropriate salt form for a potential drug candidate is an opportunity to modulate itscharacteristics to improve bioavailability, stability, manufacturability, and patient compliance. In the present studyprulifloxacin was subjected to pharmaceutical acceptable acid fumaricacid. The fumarate salt was characterised bypowder X-ray diffraction (PXRD), infrared (IR), differential scanning calorimetry (DSC) and nuclear magneticresonance spectroscopy (1H NMR) and subsequently evaluated aqueous solubility and hygroscopicity (DVS). Theprulifloxacin fumarate salt shows better thermal characteristics and excellent solubility.
