期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：2
页码：289
DOI：10.15680/IJIRSET.2015.0402062
出版社：S&S Publications
摘要：Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast cancer. Early age atonset is generally considered an indicator of genetic susceptibility to breast cancer. We determined whether tumorpathologic features and clinical features differ in patients with and without BRCA2 mutations, the study was carried outon thirty breast cancer patients, divided as fifteen with familial breast cancer and fifteen with sporadic breast cancer.Seven cases of the familial breast cancer patients showed BRCA2 mutaion. According to this study, there wasstatistically significant negative correlation between frequency BRCA2 gene mutations and female age, there wasnegative correlation between BRCA2 gene mutations and ER receptor, PR receptor and HER2/neu status (positivity andnegativity) and positive correlation between gene mutations and the pathological grade of the tumor. However, thiscorrelation did not reach a significant level. Three of the seven BRCA2 patients weRe of triple negative molecular type(from total 5patient had triple negative type among the thirty patients). The ER positive BRCA2 patients were mainlyluminal B.
