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  • 标题:Synthesis and Biological Evaluation of New 2-(5-fluoro-2-methyl-lH-inden-3-yl) Acetohydrazide Derivatives
  • 本地全文:下载
  • 作者:R. B. Kawde ; D. V. Patil ; J. K. Patil
  • 期刊名称:International Journal of Innovative Research in Science, Engineering and Technology
  • 印刷版ISSN:2347-6710
  • 电子版ISSN:2319-8753
  • 出版年度:2015
  • 卷号:4
  • 期号:5
  • 页码:3525
  • DOI:10.15680/IJIRSET.2015.0405108
  • 出版社:S&S Publications
  • 摘要:Compound 2-(5-fluoro-2-methyl-1H-inden-3-yl) acetohydrazide was reacted with various substitutedaldehydes at elevated temperature in methanol to yield substituted N-benzylidene-2-(2-methyl-1H-inden-3-yl)acetohydrazide as sole product. It is also observed that reaction went to completion during 8-10 hrs at reflux conditionwithout adding any acid or base catalyst. The reaction condition found general for all the substituted benzaldehyde.These derivatives are found more than 80% in yield. These new compounds are studied for the antimicrobial activity.
  • 关键词:Acetohydrazide; methanol ; antimicrobial activity.
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