期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：7
页码：6255
DOI：10.15680/IJIRSET.2015.0407132
出版社：S&S Publications
摘要：Liver is the most important organ, which plays a pivotal role in regulating various physiologicalprocesses in the body. Living in a world of inadequately controlled environment, pollution and expanding therapy withpotent drugs, it is continuously exposed to variety of xenobiotics and therapeutic agents resulting in its structural orfunctional damage. In an attempt to establish its pharmacological potential, we studied the hepatoprotective activity ofethanolic extract of Phyllanthus niruri obtained via extraction of leaves. The extract exhibited significant (p < 0.05)dose-dependent hepatoprotective activity for the CCl4 induced model. In alcholic extract of treated groups there wasstatistical significant decrease in the levels of serum bilirubin, serum glutamate oxaloacetate transminase (SGOT),serum glutamate pyruvate transminase (SGPT) and serum alkaline phosphatase (SALP) as compared to the hepatotoxicgroup. In the liver by a significant reduction in the activity levels of superoxide dismutase, catalase, glutathioneperoxidase, gluthaione-s-transferase, glutathione reductase and also reduced glutathione content were observed in theliver of CCl4 intoxicated rats over the control. The alcoholic extracts of the leaves of P. niruri possess hepatoprotectiveactivity, Anti-stress, antioxidant properties that may be due to cytoprotective mechanism. These results support theethnomedical uses of the plant in the treatment of liver. However, it suggests that a dose adjustment may be necessaryto optimize the effects in clinical settings.
