期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：10
页码：9798
DOI：10.15680/IJIRSET.2015.0410068
出版社：S&S Publications
摘要：Introduction: Renal diseases affect huge populations in Morocco and abroad. Genetic polymorphisms(SNPs) in scavenger receptors such as CD36 have been implicated in the pathogenesis of diabetes, hypertension,atherosclerosis and cardiovascular diseases. Since CD36 gene expression contributes to these leading causes of kidneydisease, we proposed to study the association of two of its polymorphisms to the occurrence of nephropathy. Methods :A population of 130 controls and 132 renal disease patients from the nephrology department of Fez university hospitalwas analyzed according to clinical parameters and genotyped for two SNPs namely rs1527479 (C > T) and rs1761667(G > A) in the CD36 gene using polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP)followed by statistical analysis. Results and discussion: At least one out of the two CD36 gene polymorphisms testedrs1527479 (P1) and rs1761667 (P2) was found in 96.2% of renal patients (45.5% in the homozygous state) and 97.7%of controls (34.6% in the homozygous state). Both polymorphisms (P1 and P2) were present simultaneously in thehomozygous state in 38.64% of nephrology patients and only 1.54% of controls (p <0.001). Conclusion: Co-existenceof the two polymorphisms rs1527479 (C > T) and rs1761667 (G > A) in the homozygous state would be a powerfulpredictor of the onset of kidney disease in the Moroccan population.
