期刊名称：International Journal of Innovative Research in Science, Engineering and Technology
印刷版ISSN：2347-6710
电子版ISSN：2319-8753
出版年度：2015
卷号：4
期号：11
页码：11640
DOI：10.15680/IJIRSET.2015.0411141
出版社：S&S Publications
摘要：Inspite of several dosage forms available in the market for effective localized action, the lozenges finds aspecial importance as they are the best dosage forms for formulating large dose medicaments. The anatomy of mouthand cheek favours easy absorption of drug, reducing the systemic absorption thus ensuring a better patient complianceespecially for paediatrics and geriatrics. Lidocaine mechanism of action suites this type of formulation and easilyabsorbed in oral cavity. Preformulation studies are primarily done to investigate the physicochemical properties of drugand to establish its compatibility with other excipients. Lidocaine (DRUG) was mixed with all excipients, used in theformulation in different ratios and subjected to FTIR Physical observation. It was observed that there is no colourchange and drug degradation as the peaks remained the same in the FTIR graphs. Lidocaine hard candy lozenges wereprepared by heat fusion method using sugar as a base. The usage of corn syrup in the formulation made the lozengestransparent and smooth, which helped in improving the elegancy of formulation. The controlled release of medicamentfrom Lozenges was achieved by using polymers like methyl cellulose, locust bean gum, HPMC K4M and xanthan gum.The prepared lozenges were subjected to physico-chemical as well as in vitro drug release study. Among all theformulations of hard candy lozenges FL8 showed the in vitro release of 98.7% at the end of 25 minutes.
