标题：SYNTHESIS AND ANTITUMOR ACTIVITY OF COPPER, NICKEL AND COBALT COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)- ETHANONE N(4)-ALLYL-3-THIOSEMICARBAZONE
期刊名称：Studia Universitatis Moldaviae: Stiinte Exacte si Economice
印刷版ISSN：1857-2073
电子版ISSN：2345-1033
出版年度：2015
期号：1(81)
页码：210-215
出版社：Moldova State University
摘要：The paper presents the synthesis of the ligand 1-(2-hydroxyphenyl)ethanone N(4)-allyl-3-thiosemicarbazone (H2L)and six coordination compounds of copper, nickel and cobalt with this ligand. The structure of thiosemicarbazone H2Lwas studied using 1H and 13С NMR spectroscopy. The synthesized coordination compounds were studied using elementalanalysis, gravimetric analysis of water content, molar conductivity, and magnetochemistry. For H2L the antitumoractivity towards human leukemia HL-60 cells and cervical cancer HeLa cells was determined. It was established that thesubstitution of hydrogen atom with methyl group in the azomethinic fragment leads to the growth of antitumor activity.
