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  • 标题:SYNTHESIS AND BIOLOGICAL ACTIVITY OF NICKEL AND COPPER COORDINATION COMPOUNDS OF 5-NITROFURAN-2-CARBALDEHYDE N(4)-ALLYL-3-THIOSEMICARBAZONE
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  • 作者:Vasilii GRAUR ; Elena ZARICIUC ; Victor TSAPKOV
  • 期刊名称:Studia Universitatis Moldaviae: Stiinte Exacte si Economice
  • 印刷版ISSN:1857-2073
  • 电子版ISSN:2345-1033
  • 出版年度:2014
  • 期号:6(76)
  • 页码:119-123
  • 出版社:Moldova State University
  • 摘要:The paper presents the synthesis of the ligand 5-nitrofuran-2-carbaldehyde N(4)-allyl-3-thiosemicarbazone (HL) and eight coordination compounds of copper(II) and nickel(II) with this ligand. The structure of thiosemicarbazone HL was studied using 1H and 13С NMR spectroscopy. For the synthesized compounds their antimicrobial and antifungal activity was studied on a series of standard strains. For HL and Cu(HL)2(NO3)2 the antitumor activity towards human leukemia HL-60 cells was estimated. It was established that coordination compounds manifest better activity than free ligand
  • 关键词:complexes; 5-nitrofuran-2-carbaldehyde; thiosemicarbazone; biological activity
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