期刊名称：Studia Universitatis Moldaviae: Stiinte Exacte si Economice
印刷版ISSN：1857-2073
电子版ISSN：2345-1033
出版年度：2012
期号：6(56)
页码：82-86
出版社：Moldova State University
摘要：Nine hydrazones have been obtained on the basis of 2-hydrazinobenzothiazole. The obtained hydrazones inhibits thegrowth of HL-60 cells of human leukemia myeloid within the concentrations of 10-5-10-6 mol/l. The highest activityshowed the compounds obtained on the basis of carboxy-2-pyridine and less activity on the basis of salicylic aldehyde. Theproperties of compounds represent an interest for medicine in terms of expanding of an arsenal of inhibitors of humanleukemia HL-60 myeloid. The hydrazones manifest comparable activity with such drugs as doxorubicin (Doxo) used inmedicine for the leukemia treatment. The replacement of pycolidinic fragment of azomethine with salicylidinic fragmentincrease the antimicrobial activity, and with dimethilaminobenzenic fragment decreases the microbial activity. The greatersensitivity in comparison with synthesized substances has expressed gram-positive microorganisms (Staphylococcusaureus (ATCC 25923), Bacillus cereus (ГИСК 8035)).
