出版社：State Institution “O.M. MARZEYEV INSTITUTE FOR PUBLIC HEALTH OF THE NAMS OF UKRAINE"
摘要：Objective of the work – assessment of individual and population carcinogenic risk for health from the effect of drinking water quality by the index of chloroform content as a prior COC. Materials and methods. The results of statistical study for the structure and dynamics of total oncology morbidity and by target organs by age categories of the population of the cities of Cherkassy and Chernigov were used. Chloroform drinking water pollution in the cities under investigation with the surface (Cherkassy) and underground (Chernigov) water supply was carried out on the basis of long-term monitoring. Risk assessment was performed by classical scheme according to the agreed-upon methodologies. Results. Dependence among formation of oncology morbidity in the settlements with surface water intake and drinking water pollution with COC has been determined. It was revealed that index of primary oncology morbidity in Cherkassy has a strong tendency to growth in all age groups. Indices of total oncology morbidity and by target organs in the persons using drinking water with an over standard content are greater by 1.2-2.5 fold than analogical indices in Ukraine, in Cherkassy and Chernigov regions and in the city of Chernigov. The levels of the individual risk of the effect of water peroral way of chloroform intake into the organism in the city with the surface water intake are greater by 90 fold than analogical index in the settlements with the underground water intake and makes up 3.62×10-5. A total individual carcinogenic risk of combined effect of water pipe drinking water chloroform, including inhalation and transdermal routes of exposure, is at the level of 4.2×10-4. Conclusions. It is demonstrated that a level of COC (chloroform) pollution of drinking water has a significant contribution in the formation of a higher malignant tumor morbidity. The regions which use a surface drinking water need an elaboration of the effective combined measures for a decrease of disease risk and making of optimum management decisions for the improvement of sanitary-and-hygienic situation.
