出版社：State Institution “O.M. MARZEYEV INSTITUTE FOR PUBLIC HEALTH OF THE NAMS OF UKRAINE"
摘要：We elucidated the possible mechanisms of benzo(a)pyrene influence on the formation of thyroid cancer morbidity in the population. Materials and Methods: Analysis of our own and literary data. We applied the method of theoretical analysis of the scientific and methodological literature (compilation, synthesis and abstraction) on the biological effects of this compound and the regularities of their manifestation. Results. The results of the performed analysis allowed to suppose that under chronic enter of benzo(a)pyrene into the organism it may produce different effects leading to a disturbance of synthesis and a decrease of thyroid hormones’ levels, that cause the activation of the thyrocites’ proliferation, development of hyperplasia, goiter. Besides, carcinogen induces also genetic and epigenetics changes in the invariable and proliferating cells at the thyroid nodal diseases, and mutations are their consequences. Stable induction of mentioned changes and simultaneous availability of the disturbances of immune system, caused by carcinogen and may promote a contribution of carcinogen together with the effect of other factors into increase of the risk and acceleration of the development of thyroid cancer in the population.
