出版社：State Institution “O.M. MARZEYEV INSTITUTE FOR PUBLIC HEALTH OF THE NAMS OF UKRAINE"
摘要：Development and use of the standardized reference samples are one of the actual elements of the system providing a quality of medicines. Sensitivity of microorganisms, included in the composition of the agent, to the antimicrobial preparations is an important feature at the choice of probiotic preparations and assessment of their efficiency. Objective. We studied a sensitivity of lactic acid bacteria strains – B. bifidum and E. faecium, selected for the creation of the standard reference samples of probiotic microorganisms, to the basic groups of modern antimicrobial agents. Results. The obtained results testify that the studied strains were sensitive respectively to 42% (B.bifidum) and the 43% (E.faecium) of the preparations actively used in clinical practice. Determination of the probiotic strains’ sensitivity to the antimicrobial preparations can be an additional epidemiologic marker for the selection of the antimicrobial treatment regimens, performance of the epidemiological monitoring of pathogenes.
