摘要:Background: The World Health Organization (WHO) initiated the Expanded Program on Immunization (EPI) in 1974. It has been widely used in different studies. Along with this, other survey methodologies have been compared to study immunization coverage at different regions. To consider different survey methodologies, one of the most important factors is the cost incurred that survey methodology. A survey method is considered as more efficient or better than the other survey method if the cost incurred in a particular method is less than the other one. Methods: In this study, cost incurred in two stage (30 × 30) cluster sampling and systematic sampling methods have been compared using a cost function for measles vaccine coverage. Measles vaccine coverage data has been taken from the survey “Comparison of Two Survey Methodologies to Estimates Total Vaccination Coverage” sponsored by Indian Council of Medical Research (ICMR), New Delhi. Results: The results show that there are no significant differences between the point estimates of measles vaccine coverage under the considered survey methodologies. But the cost incurred in systematic sampling is more than that of two stage cluster sampling. Conclusion: It can be concluded that systematic sampling survey is costlier than that of two stage cluster sampling for this study population.