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  • 标题:EFFECTS OF OMEGA-3 FATTY ACIDS SUPPLEMENT ON ANTIOXIDANT ENZYMES ACTIVITY IN TYPE 2 DIABETIC PATIENTS
  • 本地全文:下载
  • 作者:TOORANG FATEMEH ; DJAZAYERY ABOLGHASSEM ; DJALALI MAHMOUD
  • 期刊名称:Iranian Journal of Public Health
  • 印刷版ISSN:2251-6085
  • 电子版ISSN:2251-6093
  • 出版年度:2016
  • 卷号:45
  • 期号:3
  • 页码:340-345
  • 语种:English
  • 出版社:THE SCHOOL OF PUBLIC HEALTH, TEHRAN UNIVERSITY OF MEDICAL SCIENCES
  • 摘要:Background: Diabetes is a major cause of death. Oxidative stress mainly caused by hyperglycemia is the primary rea-son of related complications. Omega-3 fatty acids are prescribed in diabetes but the effect on antioxidant defense is controversial. This study investigated effects of omega-3 supplementation on antioxidant enzymes activity in type 2 diabetic patients.
    Methods: A randomized, placebo controlled, double blind clinical trial was performed on 90 type2 diabetic patients. The treatment group took, daily, three capsules of omega-3 for two mo, which totally provided 2714mg omega-3 (EPA=1548 mg, DHA=828 mg and 338 mg of other omega=3 fatty acids). Placebo contained 2100 mg sunflower oil (12% SFA, 65% linoleic acid, 23% MUFA), which is the main oil used in the study population. Food intakes, anthro-pometric and demographic characteristics, and therapeutic regimen data were recorded before and after the interven-tion. Fasting blood samples were taken before and after the intervention to measure super oxide dismutase, gluta-thione peroxidase, glutathione reductase, catalase and total antioxidant capacity in erythrocytes.
    Results: A total of 81 subjects completed the study. Two study groups were similar as regards duration of diabetes, age and the enzymes at baseline. Energy and macro- and micronutrients intakes, weight and hypoglycemic agent con-sumption were similar in the two groups at baseline and did not change. Supplementation had no effect on antioxidant enzyme status. Glycated hemoglobin showed a significant reduction by supplementation.
    Conclusion: Daily supplementation of 2714 mg mega-3 for two mo results in a significant reduction in HbA1c level in type2 diabetic patients with no effects on antioxidant enzymes activity.
  • 关键词:TYPE 2 DIABETES; OMEGA-3 SUPPLEMENT; ANTIOXIDANT ENZYMES
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