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  • 标题:EFFECT OF OMEGA-3 SUPPLEMENTATION ON LIPOCALIN 2 AND RETINOL-BINDING PROTEIN 4 IN TYPE 2 DIABETIC PATIENTS
  • 本地全文:下载
  • 作者:FARAHBAKHSH FARSI PAYAM ; DJAZAYERY ABOLGHASSEM ; ESHRAGHIAN MOHAMMAD REZA
  • 期刊名称:Iranian Journal of Public Health
  • 印刷版ISSN:2251-6085
  • 电子版ISSN:2251-6093
  • 出版年度:2016
  • 卷号:45
  • 期号:1
  • 页码:63-69
  • 语种:English
  • 出版社:Tehran University of Medical Sciences
  • 摘要:Background: Serum levels of lipocalin 2 (LCN 2) and retinol-binding protein-4 (RBP 4), increase in type 2 diabetes mellitus (T2DM). We sought to determine whether serum LCN 2 and RBP 4 change after an intervention with omega-3 fatty acids supplementation in diabetic patients.
    Methods: Forty-five type 2 diabetic patients from Iranian Diabetic Association in Tehran, Iran in 2013 were randomly recruited into two groups: one group received 4 g/d omega-3 for 10 wk; and the control group received placebo. Blood samples, food intake records, anthropometric measurements were obtained from all participants at the begin-ning and end of the study.
    Results: Fasting RBP 4 plasma levels significantly changed after 10 wk supplementation (P=0.01). The LCN 2 con-centrations decreased in omega-3 group, but the changes were not statistically significant. Omega-3 supplementation had no noticeable effect on anthropometric factors.
    Conclusions: These findings provide a rationale for omega-3 supplements aimed at lowering serum RBP 4 levels in T2DM.
  • 关键词:OMEGA-3 FATTY ACID; LIPOCALIN; RETINOL-BINDING PROTEIN; DIABETES MELLITUS
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