The paper summarises the results of Palaeolithic research in Vídeňská (former Koněvova) Street in the city of Brno. After the first small-scale excavations carried by K. Valoch in 1972, primarily rescue excavations in recent years (2009–2014) have revealed the extent and intensity of the Palaeolithic settlement. The specific features of the locality are represented by imported raw materials, a high frequency of burins compared to other tools and a predominance of Mammuthus primigenius among the faunal remains. The settlement was earlier classified as Epigravettian which is confirmed by new radiocarbon dating. Based on the knowledge obtained in the immediate neighbourhood of the locality, it became apparent that this convenient area near the river repeatedly attracted people to build settlements in these places, in all probability specialised groups of hunters. Despite the climatically unfavourable final part of the LGT period (after a definition by Markova et al. 2013), within which the settlement at Brno-Štýřice III falls based on radiocarbon dating and malacofauna, we can take into consideration a denser settlement strategy than is usually assumed in the broader context of the Middle Danube Region.