出版社：European HIV/AIDS and Infectious Diseases Academy
摘要：1933 – Boivin A, Mesrobeanu I and Mesrobeanu L describe a toxic factor enclosed in the outer membrane of Gram-negative bacteria – nowadays known as endotoxin. Ever since, researchers have tried to employ mechanisms to neutralize this endotoxin and thus limit the progression of disease in patients with sepsis due to Gram-negative bacilli. Meanwhile, the use of antibiotics over the past decades has lead to the emergence of resistance, multidrug resistance, extensive resistance and pan resistance.
