摘要：This study aims at determining biochemical parameters of rats fed with bread in which the wheat flour has been substituted by Citrullus lanatus defatted cake at different proportions (0 %, 5 %, 10 %, 15 % and 20 %). Thirty rats (30) teamed up into five per group were fed during 14 days with the six different diets. Control diet made with casein like protein source (RTC); diet containing classic bread based on wheat flour (RPC); and diets based on bread in which the wheat flour has been substituted by defatted cake of Citrullus lanatus with different proportions (RPFd). At the end of the experimental period, animals were sacrificed and blood sample were collected for glucose, urea, creatinine, total-cholesterol, triglyceride, calcium and phosphorus analyses. Glycaemia of rats fed with diets RTC (1.24±0.13 g/l) and RPC 1.09±0.07 g/l) were significantly superior (p≤0.05) to that of rats fed with diets RPFd (0.24±0.11 g/l to 0.28±0.06 g/l). Uraemia of rats fed with diet RPFd were significantly inferior to that of rats fed with diets RTC (0.39±0.15 g/l and RPC (0.47±0.11 g/l). As for creatinineamia, it was not significant between values obtained on rats fed with diets RTC and RPC and that obtained on rats fed with diets RPFd. Cholesterolemia of rats fed with diets RTC and RPC were significantly superior (p≤0.05) to that of rats fed with diets RPFd. There was no significant difference between triglyceride of rats fed with the different diets which were constituted. The ratio calcium/phosphorus of rats fed with the different diets were between 1.26±0.12 and 2.45±1.47 and did not show any significant difference. This study showed that wheat flour bread fortification with defatted cake of Citrullus lanatus modifies blood biochemical parameters. Complementary studies will be useful to determine if these modifications could provoke some effects on physiological functionalities of nutritional regulating organ.
