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  • 标题:Anti-inflammatory Prenylated Flavonoids from Helminthostachys zeylanica
  • 本地全文:下载
  • 作者:Li-Hua Su ; Yan-Ping Li ; Hong-Mei Li
  • 期刊名称:Chemical and Pharmaceutical Bulletin
  • 印刷版ISSN:0009-2363
  • 电子版ISSN:1347-5223
  • 出版年度:2016
  • 卷号:64
  • 期号:5
  • 页码:497-501
  • DOI:10.1248/cpb.c15-00661
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:Two new [neougonins A ( 1 ) and B ( 2 )] and nine known prenylated flavonoids were isolated from the whole plants of Helminthostachys zeylanica . The structures of the new isolates were elucidated by extensive NMR techniques, including one and two dimensional (1D)- and (2D)-NMR experiments, as well as comparison with spectroscopic data of known analogous compounds. Moreover, compound 1 inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells with an IC50 value of 3.32 µM.
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