期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2004
卷号：2
期号：1
页码：66-71
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Current knowledge of the response to an allograft is based on our understanding of the immune response to any exogenous antigen (Figure 1). The key cells involved in the immune response to an allograft are dendritic cells, macrophages, and lymphocytes. Lymphocytes can be divided into a number of functional populations. The thymus-derived (T) lymphocytes can be broadly divided into helper T lymphocytes (TH or CD4+), characterized by the expression of the CD4 molecule, and cytotoxic T lymphocytes (TC or CD8+), characterized by the expression of the CD8 molecule. Bone-marrow-derived (B) lymphocytes differentiate into plasma cells which produce antibody in response to antigen stimulation. The TH cells can be further subdivided into TH1 and TH2 lymphocytes based on the pattern of cytokines produced by the cells. TH1 cells produce IL-2 and γ-interferon, while TH2 cells produce IL-4 and IL-101. These two subpopulations of TH lymphocytes have the capacity to regulate each other’sactivity.
