期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2006
卷号：4
期号：2
页码：71-74
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Definition: Antiphospholipid syndrome (APS) (Hughes syndrome) is a disorder characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with typical laboratory abnormalities.Frequency: Actual frequency in the general population is unknown. Antiphospholipid (aPL) antibodies can be found in 1-5% of the healthy population. Anticardiolipin (aCL) antibody tends to occur more frequently in elderly individuals. Recent literature suggests that the occurrence rate of APS in patients with SLE is 34-42%. Antiphospholipid antibody-related thrombosis seems to constitute a significant proportion of childhood thromboses. About one third of children suffering a thrombotic event have circulating antiphospholipid antibodies, and more than two thirds of children with idiopathic cerebral ischemia meet the criteria for the diagnosis of antiphospholipid antibody syndromeSex: A female predominance is documented, particularly for secondary APS. This parallels the association of APS with SLE and other connective-tissue diseases, which also have a female predominance.
