期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2011
卷号：9
期号：2
页码：87-92
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Thyroid autoimmune diseases have been associated withsystemic lupus erythematosus (SLE). Both hypothyroidism andhyperthyroidism are seen, but hypothyroidism is the most commonabnormality. Subclinical hypothyroidism (SCH) has been reported amongadult lupus patients. SCH is not without risk as it might contribute to a proatherogenicstate. Objectives: This study was aimed to assess the frequencyof SCH in a group of Egyptian children with SLE and its effects on theserum lipids. Methods: Forty patients with pediatric SLE who regularlyfollow up at our center were enrolled in this study. They were subjected toroutine laboratory investigations of SLE and measurement of serum lipids(serum triglycerides, cholesterol, LDL and HDL) as well as free thyroxine(T4), thyroid stimulating hormone (TSH) and anti-thyroperoxidase antibody(anti-TPO-ab) titre. SLE activity was assessed using the systemic lupuserythematosus disease activity index (SLEDAI). Results: Six patients (15%)were found to have SCH while the remaining 34 patients (85%) had normalthyroid function. Anti-TPO-abs were positive in 4 out of the 6 (66.6 %) SLEpatients with SCH and in 20 out of the 34 (58.8%) SLE patients with normalthyroid function. In SLE patients with SCH, TSH correlated positively yetinsignificantly with anti-TPO-ab titre and the duration of SLE (p= 0.17, p=0.12, respectively). There were no statistically significant correlationsbetween the serum lipids of SLE patients with SCH and their thyroidfunction or anti-TPO-ab titre. Conclusion: SCH is not uncommon amongchildren with SLE. This SCH does not seem to affect serum lipids. However,further longitudinal studies on wider scales are needed to assess the longterm effects of SCH in those patients.
