期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2011
卷号：9
期号：2
页码：98
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：I read with interest the published article by El-Sayed et al.1 in your journal recently. Soon afterintroducing recombinant hepatitis B virus (HBV)vaccine, universal neonatal vaccination became thecornerstone of the preventive measures for controlof HBV infection2. By 2006 more than 177 out of193 member states of the World HealthOrganization (WHO) introduced HBV vaccinationin their national infant immunization programs2.The measurement of post vaccination serum levelof anti-hepatitis B surface antibody (anti-HBs) isthe only simple test available to predict the waningof protection and help plan for the administration ofa booster dose especially in high risk groups3. Alevel of 10 IU/L of anti HBsAb is usuallyconsidered as a protective level against futureinfections. The reported rate of persistent protectivelevel of anti HBsAb titers varied from 33% up to79%, at least 5 years after vaccination2.It is obvious that the percentage of negative antiHBsAb after 10 years would be more than that in 5years after HBV vaccination. The main question isabout the rate of HBs Ag seroconversion in thisgroup, which is confirmed to be decreasingsignificantly in all studies. Furthermore, the morecoverage of HBV vaccination especially in ruralareas is a key point in this achievement. Fortunatelythe anti HBsAb after vaccination was significantlyhigh in most children especially in group A after 5years of HBV vaccination.
