期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2012
卷号：10
期号：1
页码：3-12
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Histamine is a key mediator in allergic diseases,where it exerts most of its effects through the H1receptor and to a less extent the H2 receptor. H1-antihistamines provide rapid relief of many of theallergic symptoms and are considered the mainstay of treatment of allergic rhinoconjunctivitisand urticaria. H1 antihistamines comprise firstgeneration (old) and second generation (new) H 1antihistamines with different pharmacologicalaspects, efficacy and safety profile. Few studiesdealt with H1 antihistamines in pediatricpopulation. This review will highlight thecharacteristics of H1 antihistamines and theirindications in pediatric allergic disorders
