期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2013
卷号：11
期号：2
页码：53-61
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Mast cells are multifunctional cells that initiate notonly IgE dependent allergic diseases but also play afundamental role in innate and adaptive immuneresponses to microbial infection. They are alsothought to play a role in angiogenesis, tissueremodeling, wound healing, and tumor repression orgrowth. The broad scope of these physiologic andpathologic roles illustrates the flexible nature of mastcells, which is enabled in part by their phenotypicadaptability to different tissue microenvironments andtheir ability to generate and release a diverse array ofbioactive mediators (Figures 1 and 2) in response tomultiple types of cell surface and cytosolic receptors.1Mast cells are tissue fixed effector cells of allergicand other inflammatory reactions. In common withblood basophils mast cells express high affinityIgE-binding sites and store numerousproinflammatory and vasoactive mediators in theirmetachromatic granules
关键词：During a severe anaphylactic reaction; allergen;induced cross linking of IgE binding sites on mast
