期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2013
卷号：11
期号：2
页码：69-73
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Vitamin D plays a role in the pathogenesis of asthma as it hasa potent immunomodulatory effect acting on the cells of the innate immunity.It also reduces the risk of respiratory viral infections which are importantinitiators of asthma exacerbations. Besides, it potentiates the antiinflammatoryaction of corticosteroids which are considered the mosteffective controllers of asthma. Objective: To detect the frequency of vitaminD insufficiency and deficiency among Egyptian asthmatic children and tocorrelate vitamin D levels to the severity of asthma. Methods: This casecontrol study was conducted on 60 asthmatic children and 40 healthycontrols. All were subjected to clinical history taking including history ofsun exposure and asthma medications and full clinical examination.Laboratory investigations included measurement of serum calcium, serumalkaline phosphatase and serum 25-OH-D levels and lung functions(spirometery). Results: There was a significant correlation between vitaminD deficiency and severity of asthma, yet there was no significant relationbetween sun exposure and 25-OH-D level. Moreover, there was a significantrelation between decreased serum 25-OH-D levels and the intensity ofcorticosteroid use. Vitamin D was also significantly lower in asthmaticpatients with coexistent allergic rhinitis. Conclusion: Vitamin D deficiencyis prevalent in Egyptian children with asthma .Lower levels of serum vitaminD are associated with high asthma severity, reduced asthma control andincreased corticosteroid use.
关键词：Vitamin D; Bronchial asthma; Egyptian; Children
