期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2013
卷号：11
期号：2
页码：95
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Mast cells (MCs) are specifically involved in type I hypersensitivity reactions where they release their granule contents of histamine and heparin, and synthesize and secrete other mediators into the surrounding tissues. Mast cells are also involved in delayed hypersensitivity, cytotoxicity, immunoregulation and inflammation 1 . A role is now defined for MCs in controlling dendritic cell (DC) behavior ("conditioning") to facilitate tolerance. Under tolerant conditions, MCs mediate a marked increase in tumor necrosis factor-dependent accumulation of graft-derived DCs due to the local production of granulocyte macrophage colony-stimulating factor by MCs that induces a survival advantage of graft-derived DCs 2
