期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2014
卷号：12
期号：1
页码：3-12
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Leukotrienes are potent pro-inflammatory lipid mediators derived from arachidonic acid through several enzymatic pathways. They have an essential role in allergic inflammation, where they induce bronchoconstriction, airway edema, and chemotaxis of the inflammatory cells in the airways, nasal and conjunctival tissues. Leukotriene modifiers include leukotriene receptor antagonists (montelukast, zafirlukast and pranlukast) and leukotriene synthesis inhibitors (zileuton). These medications have been extensively used in childhood allergic diseases. This review will highlight the leukotriene pathway and its role in allergy as well as the effects of leukotriene modifiers in different allergic disorders
