期刊名称：Egyptian Journal of Pediatric Allergy and Immunology
印刷版ISSN：1687-1642
电子版ISSN：2314-8934
出版年度：2015
卷号：13
期号：1
页码：3-6
出版社：Egyptian Society of Pediatric Allergy and Immunology
摘要：Age groups vulnerable to serious attacks of anaphylaxis include infants, teenagers, pregnant women, and the elderly. Concomitant diseases, such as severe or uncontrolled asthma, cardiovascular disease, mastocytosis or clonal mast cell disorders and the concurrent use of some medications such as beta adrenergic blockers and angiotensin-converting enzyme (ACE) inhibitors increase the risk of severe or fatal anaphylaxis.1,2 Also, defects in mediator degradation pathways might predispose to severe or fatal episodes resulting in elevated baseline levels of tryptase, histamine, bradykinin (due to low serum ACE activity), and platelet-activating factor (PAF) due to low serum PAF acetyl hydrolase activity
